The comparative effect of different types of honey on levels of glucose, fructosamine and insulin in Streptozocin-induced diabetes in wistar rats

Abstract

The prevalence of diabetes is increasing rapidly. Diabetic patients are deprived of sugar sweetener consumption due to their high blood sugar. Choosing appropriate substitutes in the meal plan of diabetic patients is one of the important therapeutic strategies. The purpose of this study was to evaluate the effect of different types of honey on the concentration of glucose, fructosamine and insulin of diabetic rats. This study was an interventional clinical trial animal study. In this study, 32 Wistar rats were used, which were divided into 4 groups. The drug of Streptozocin was used to induce diabetes in 4 groups of rats. Three types of Acacia honey, Astragalus honey, and Nodushan Yazd honey were used in 3 groups of diabetic rats and 1 group also was considered as control groups of diabetic and normal groups. Difference in blood Fructosamine of diabetic rats was not significant in the receiver groups of different types of honey. On the other hand, the Astragalus honey consumption significantly increased glucose and the Nodushan honey consumption significantly increased insulin concentration in diabetic rats. The present study showed that some types of honey do not have any negative effect on blood glucose concentration of diabetic rats, but they cause an increase in serum insulin concentration. Based on the findings of this study, it is recommended that some types of honey can be used as a safe natural sweetener and even can be beneficial.